Welcome to the Smrcka Lab

Our laboratory studies mechanisms for cellular communication via G protein coupled receptors (GPCRs). The GPCR superfamily includes receptors for adrenaline, serotonin, acetylcholine, taste molecules, smell, and even light! They are the largest family of cell surface receptors and 30-40% of marketed drugs target GPCRs. Our laboratory uses a wide variety of methods to study the involvement of these receptors in physiology and disease. We provide a dynamic environment where trainees can gain experience in a wide repertoire of methods applied to important biological problems. Learn more ยป


June 2024: We are heading to the “Protein Phosphorylation and G protein-Mediated Signaling Networks” Gordon Research Conference June 8-14. Should be a GREAT conference.

May 2024: Wei’s paper on the cardioprotective mechanism of beta2 adrenergic receptors was accepted for publication in Circulation Research. Congratulations Wei!

March 2024: Tyler’s paper on the molecular nature of Gi subunit specificity was published in the Journal of Biological Chemistry. Great work Tyler!