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Welcome to the Smrcka Lab

Our laboratory studies mechanisms for cellular communication via G protein coupled receptors (GPCRs).  The GPCR superfamily includes receptors for adrenaline, serotonin, acetylcholine taste molecules, smell, and even light!  They are the largest family of cell surface receptors and 30-40% of marketed drugs target GPCRs.  Our laboratory uses a wide variety of methods to study the involvement of these receptors in physiology and disease.  We provide a dynamic environment where trainees can gain experience in a wide repertoire of methods applied to important biological problems. Learn more »


Led by Dr. Adrian Campbell the Smrcka Laboratory has recently received a grant from the UM Center for Discovery of New Medicines to develop G protein inhibitors as novel treatments for pain.