THE LAB 2018-07-03T13:00:43+00:00

Alan Smrcka, Ph.D.

Professor
avsmrcka@umich.edu
734-615-4945
5560C MSRB II

Alan received his Ph.D. in Biochemistry from the University of Arizona and did a Postdoctoral Fellowship with Paul Sternweis at The University of Texas Southwestern Medical Center where he studied G proteins and phospholipase C.

Saji Abraham, Ph.D.

Research Lab Specialist 
Intermediate
Saji@umich.edu
734-764-9925
5554 MSRB II

Saji received his Ph.D is in Botany in 2001 From Mahatma Gandhi University, India.  He is currently working on purifying G proteins for protein crystallization.

Richard Ransom, Ph.D.

Assistant Research Scientist
rransom@umich.edu
734-764-9925
5558 MSRB II

Richard received his Ph.D. in Biochemistry from Purdue University in 1991, and did postdoctoral work at the University of California, Riverside, and Michigan State University on fungal host-selective, cyclic-peptide toxins.  He has held faculty positions at the University of Michigan and at The Ohio State University prior to joining the Smrcka lab in 2017.  His previous areas of interest include fungal plant pathology, cyclic peptide toxins, kidney glomerular disease, and the mechanism of action of glucocorticoid therapies.  His current projects include investigations of signaling mechanisms by phospholipase C and the regulation of phospholipase C epsilon.

Michael Burroughs

Research Lab Specialist Assoc.
mburrou@umich.edu
734-764-9925
5558 MSRB II

Michael has a degree in Biochemistry from SUNY Binghamton.  He is a Lab Research Specialist Associate with experience in screening, protein purification, and rodent colony management.

Craig Nash, Ph.D.

Research Investigator
canash@umich.edu
734-764-9925
5558 MSRB II

Craig completed his PhD at the University of Birmingham, UK in 2011 and after a 3-year post-doc at the University of Leicester, UK, joined the Smrcka lab in February 2015. His current project is focused on the regulation of PLCe by cAMP-mediated pathways, particularly the interplay between positive and negative signals from cAMP.

Adrian Campbell, Ph.D.

Research Fellow
apcamp@umich.edu
734-764-9925
5558 MSRB II

Adrian received his PhD from University of New South Wales, where he characterized a novel family of allosteric modulators for the α1-adrenergic receptors. He is currently undertaking a drug development project, looking for small molecule inhibitors of Gβγ. These compounds can be used for further elucidation of the physiological roles of Gβγ, as well as potential application in the treatment of pain, cardiac hypertrophy and inflammatory conditions.

Loren Brown PhD

Postdoc

Loren conducted his PhD studies in the laboratory of Dr. Paul Insel in the Department of Pharmacology at UC San Diego. He is currently interested in elucidating the mechanisms by which different GPCRs signal through G proteins to induce cardiac hypertrophy.

Naincy Chandan

Graduate Student
nchandan@umich.edu
734-764-9925
5554 MSRB II

Naincy received her bachelors and masters degree in Biotechnology, from India. She joined the Smrcka laboratory in April 2016 and is currently pursuing two diverse projects: A translational project which is based on the development of peptidomimetic inhibitor to prevent cardiac hypertrophy and a cell-biology project to understand Gαi regulation of immune cell migration.

Isaac Fisher

Graduate Student (URMC)
ifisher@umich.edu
734-764-9925
5558 MSRB II

Isaac graduated from Slippery Rock University in 2012.  He is currently working on understanding the mechanism of PLCb activation by G-proteins.

Tyler Lefevre

Graduate Student in the Program in Chemical Biology
tlefevre@umich.edu
734-764-9925
5556 MSRB II

Tyler received Bachelor of Science in Biochemistry in May 2017 from Saginaw Valley State University, University Center, MI.  Tyler joined the laboratory in April of 2018 and is working on small molecule discovery for targeting G protein subunits

Soneida Rodriguez

Undergraduate Researcher
soneida@umich.edu
734-764-9925
5554 MSRB II

Soneida is a participant in the University of Michigan Research Opportunity Program (UROP).  She is studying the role of Phospholipase C in regulation of cardiac fibrosis.

Wenhui Wei

Masters Student
weiwenh@umich.edu
734-764-9925
5554 MSRB II

Wei is pursuing a Masters Degree in Pharmacology at the University of Michigan.  Her project examines intracellular signaling by intracellular GPCRs.

RECENT PAST LAB MEMBERS

Jerry Madukwe

Graduate Student (URMC)
jmadukwe@umich.edu
734-764-9925
5554 MSRB II

Jerry recently received his Ph.D. from the Department of Biochemistry at the University of Rochester.  Jerry will be doing a postdoctoral fellowship.

Jesi Lee Anne To

Successfully defended her thesis in the Department of Pharmacology and Physiology at the University of Rochester School of Medicine in April of 2018

She has taken a position Promius Pharma as a Medical Affairs Fellow. This is a 2-year fellowship, in which she will be completing rotations in scientific communications, publication operations, educational grant operations, medical information, as well as training for medical affairs field activities.

Rafael Gil de Rubio

Successfully defended his thesis in the Department of Pharmacology and Physiology at the University of Rochester School of Medicine in March of 2018.  He is currently doing a postdoctoral fellowship at the University of Michigan.