Alan Smrcka, Ph.D.
Professor avsmrcka@umich.edu 734-615-4945 5560C MSRB II Alan has been studying G proteins and GPCR pharmacology for nearly 30 years. He is dedicated to trainee mentoring and performing cutting edge science using the latest technologies. His work spans studies of the roles of GPCR signaling in cardiac, neuro, cancer and innate immune systems. He has published over 125 papers and is a Fellow of the American Society of Pharmacology and Experimental Therapeutics and holds the Benedict Luchessi Collegiate Chair of Cardiovascular Pharmacology.
Saji Abraham, Ph.D.
Research Lab Specialist Intermediate Saji@umich.edu 734-764-9925 5554 MSRB II Saji received his Ph.D is in Botany in 2001 From Mahatma Gandhi University, India. He is currently working on purifying G proteins for small molecule inhibitor discovery and analysis.
Sai Pranathi Meda Venkata, Ph.D.
Postdoctoral Fellow saimedav@umich.edu 734-764-9925 5558 MSRB II Sai received her Ph.D. in Pharmaceutical Sciences from Wayne State University. She is working on identification and characterization of Galpha subunit interaction partners using proximity labeling proteomics.
Michael Burroughs
Research Lab Specialist Assoc. mburrou@umich.edu 734-764-9925 5558 MSRB II Michael has a degree in Biochemistry from SUNY Binghamton. He is a Lab Research Specialist Associate with expertise in drug screening, protein purification and most other assays in the laboratory.
Joseph Loomis
Ph.D. Student in the Program in Chemical Biology jfloomis@umich.edu 734-764-9925 5558 MSRB II Joseph received a Bachelor of Science with a dual major in Biochemistry and Chemistry in 2019 from The University of Kansas. Joseph joined the laboratory in April of 2020 and is working on studying the signaling properties of Gq subunits in regulation of chromatin remodeling.
Nathalie Momplaisir
Ph.D. Student in Pharmacology mnlancy@umich.edu 734-764-9925 5558 MSRB II Nathalie received a Bachelor of Science in Chemistry in 2019 from Tuskegee University. Nathalie joined the laboratory in April of 2020 and is working on identifying and characterizating of G protein targets involved in neurological diseases.
Rongxi Zhang
Ph.D. Student rongxi@umich.edu 734-764-9925 5554 MSRB II Rongxi received a joint BSc in Biochemistry and Pharmacology from University of Strathclyde and China Pharmaceutical University. Rongxi is interested in studying novel protein-protein interactions of G protein alpha subunits and their roles in regulation of Ras signaling.
Elaine Qu
Undergraduate Student equ@umich.edu 734-764-9925 5554 MSRB II Elaine is an undergraduate at UM majoring in Biochemistry. She is interested in understanding the role of G proteins in developmental epileptic encephalopathies.
RECENT PAST LAB MEMBERS
Tyler Lefevre
Received his Ph.D. in Chemical Biology in 2023. Tyler worked on discovering new roles for and functional properties for determining specificity of the Gi G protein subtypes in cellular functions. Tyler is currently a Postdoctoral Fellow in Antibody Design and Engineering at Astra Zeneca
Gissell Sanchez
Received her Ph.D. in Pharmacology in 2023. Gissell worked on a project under the co-mentorship of Drs. Smrcka and Jutkiewicz in May of 2019 working development of novel treatments for opioid analgesia through targeting phospholipase C and G proteins.
Wenhui Wei
Received her Ph.D. in Pharmacology in 2023. She is currently doing a postdoctoral fellowship at the University of California at San Diego continuing to work in the field of Cardiovascular Biology.
Hoa Phan
Postdoctoral Fellow hophan@med.umich.edu 734-764-9925 5554 MSRB II Hoa is from Vietnam and completed her Ph.D. research with Dr. Richard Neubig at Michigan State working on RGS proteins. She joined the Smrcka laboratory in October 2018. She worked to understand the roles of phospholipase C mutations in cancer as well as identifying new mechanisms for PLC regulation by GPCRs. She is currently a scientist at Takeda Pharmaceuticals in San Diego.
Naincy Chandan
Ph.D. Student nchandan@umich.edu 734-764-9925 5554 MSRB II Naincy received her bachelors and masters degree in Biotechnology, from India. She joined the Smrcka laboratory in April 2016 and received her Ph.D. in Pharmacology in October of 2021. She developed a proximity labeling proteomics method for identification of new G protein Signaling Pathways. She is currently a Scientist at Genentech.
Nam Hoon Kim
Undergraduate Student namhook@umich.edu 734-764-9925 5554 MSRB II Nam is a sophomore at the University of Michigan majoring in Biochemistry with a minor in Biophysics. His project is structure function analysis of activating phospholipase C mutations. He is currently on leave in Korea and returning soon to the U of M.
Craig Nash, Ph.D.
Craig completed his PhD at the University of Birmingham, UK in 2011 and after a 3-year post-doc at the University of Leicester, UK, worked the Smrcka lab in from 2015-2020. His project focused on the regulation of PLCe by cAMP-mediated pathways, particularly focusing on regulation by intracellular GPCRs. He is currently a Research Scientist at the Broad Institute.
Isaac Fisher
Ph.D. Isaac graduated from Slippery Rock University in 2012 and earned his Ph.D. from the University of Rochester in 2020. He is currently working on understanding the mechanism of PLCb activation by G-proteins in Dr. Angeline Lyon’s laboratory at Purdue University.
Loren Brown PhD
Postdoc Loren conducted his PhD studies in the laboratory of Dr. Paul Insel in the Department of Pharmacology at UC San Diego. He is currently a Research Associate at LSU Health Science Center in New Orleans.
Soneida Rodriguez
Undergraduate Researcher Soneida is a participant in the University of Michigan Research Opportunity Program (UROP). She is studied the role of Phospholipase C in regulation of cardiac fibrosis. She is currently working in David Pinsky’s laboratory.
Richard Ransom, Ph.D.
Assistant Research Scientist Richard received his Ph.D. in Biochemistry from Purdue University in 1991, and did postdoctoral work at the University of California, Riverside, and Michigan State University on fungal host-selective, cyclic-peptide toxins. He has held faculty positions at the University of Michigan and at The Ohio State University prior to joining the Smrcka lab in 2017. His previous areas of interest include fungal plant pathology, cyclic peptide toxins, kidney glomerular disease, and the mechanism of action of glucocorticoid therapies. His studied the signaling mechanisms regulated by phospholipase C.
Adrian Campbell, Ph.D.
Research Fellow Adrian received his PhD from University of New South Wales, where he characterized a novel family of allosteric modulators for the α1-adrenergic receptors. In our laboratory he worked on a drug development project, looking for small molecule inhibitors of Gβγ. He is currently a Senior Scientist at Synature Discovery in Nottingham, UK.
Jerry Madukwe
Graduate Student (URMC) jmadukwe@umich.edu 734-764-9925 5554 MSRB II Jerry received his Ph.D. from the Department of Biochemistry at the University of Rochester. Jerry will be is a Postdoctoral Researcher at the Yale University School of Medicine where he is doing a structural biology project to elucidate mechanisms of action of receptor tyrosine kinases.
Jesi Lee Anne To
Successfully defended her thesis in the Department of Pharmacology and Physiology at the University of Rochester School of Medicine in April of 2018. She is currently a Medical Writer at INVIVO Communications in Toronto, Canada.
Rafael Gil de Rubio
Successfully defended his thesis in the Department of Pharmacology and Physiology at the University of Rochester School of Medicine in March of 2018. He is currently a Scientist at Riparian Pharmaceuticals in Cambridge, MA.