Alan Smrcka, Ph.D.

Professor avsmrcka@umich.edu 734-615-4945 5560C MSRB II Alan received his Ph.D. in Biochemistry from the University of Arizona and did a Postdoctoral Fellowship with Paul Sternweis at The University of Texas Southwestern Medical Center where he studied G protein and GPCR signaling and phospholipase C regulation using biochemical reconstitution methods.  He has continued this work incorporating live cell microscopy, molecular genetics and chemical biology methods and applying it to a wide range of biological systems regulated by G protein signaling.

Saji Abraham, Ph.D.

Research Lab Specialist  Intermediate Saji@umich.edu 734-764-9925 5554 MSRB II Saji received his Ph.D is in Botany in 2001 From Mahatma Gandhi University, India.  He is currently working on purifying G proteins for small molecule inhibitor discovery and analysis.

Michael Burroughs

Research Lab Specialist Assoc. mburrou@umich.edu 734-764-9925 5558 MSRB II Michael has a degree in Biochemistry from SUNY Binghamton.  He is a Lab Research Specialist Associate with expertise in screening, protein purification and most other assays in the laboratory.

Hoa Phan

Postdoctoral Fellow hophan@med.umich.edu 734-764-9925 5554 MSRB II Hoa is from Vietnam and completed her Ph.D. research with Dr. Richard Neubig at Michigan State working on RGS proteins.  She joined the Smrcka laboratory in October 2018.  She is currently working to understand the roles of phospholipase C mutations in cancer

Naincy Chandan

Ph.D. Student nchandan@umich.edu 734-764-9925 5554 MSRB II Naincy received her bachelors and masters degree in Biotechnology, from India. She joined the Smrcka laboratory in April 2016.  she is currently working to understand the roles of adhesion GPCRs and Gαi regulation of immune cell and cancer cell migration.

Tyler Lefevre

Ph.D. Student in the Program in Chemical Biology tlefevre@umich.edu 734-764-9925 5556 MSRB II Tyler received a Bachelor of Science in Biochemistry in May 2017 from Saginaw Valley State University, University Center, MI.  Tyler joined the laboratory in April of 2018 and is working on discovering new roles for and functional properties for determining specificity of the Gi G protein subtypes in cellular functions.

Joseph Loomis

Ph.D. Student in the Program in Chemical Biology jfloomis@umich.edu 734-764-9925 5558 MSRB II Joseph received a Bachelor of Science with a dual major in Biochemistry and Chemistry in 2019 from The University of Kansas.  Joseph joined the laboratory in April of 2020 and is working on studying the signaling properties and receptor-coupling specificity of the extra large XL splice variant of Gαs.

Nathalie Momplaisir

Ph.D. Student in Pharmacology  mnlancy@umich.edu 734-764-9925 5558 MSRB II Nathalie received a Bachelor of Science in Chemistry in 2019 from Tuskegee University.  Nathalie joined the laboratory in April of 2020 and is working on identifying novel targets for Gi signaling.

Gissell Sanchez

Ph.D. Student in Pharmacology gsanc@umich.edu 734-764-9925 5556 MSRB II Gissell received her Bachelor of Science in Neuroscience in June 2016 from The University of California, Riverside, CA.  Gissell is working on a project under the co-mentorship of Drs. Smrcka and Jutkiewicz in May of 2019 working development of novel treatments for opioid analgesia through targeting phospholipase C and G proteins.

Wenhui Wei

Ph.D. Student weiwenh@umich.edu 734-764-9925 5554 MSRB II Wei received her Masters Degree in Pharmacology at the University of Michigan. She is currently  in the Pharmacology Ph.D. program.  Her project examines intracellular signaling by intracellular GPCRs in cardiac myocytes and in mouse models.

Nam Hoon Kim

Undergraduate Student namhook@umich.edu 734-764-9925 5554 MSRB II Nam is a sophomore at the University of Michigan majoring in Biochemistry with a minor in Biophysics.   His project is structure function analysis of activating phospholipase C mutations.

RECENT PAST LAB MEMBERS

Craig Nash, Ph.D.

 Craig completed his PhD at the University of Birmingham, UK in 2011 and after a 3-year post-doc at the University of Leicester, UK, worked the Smrcka lab in from 2015-2020. His project focused on the regulation of PLCe by cAMP-mediated pathways, particularly focusing on regulation by intracellular GPCRs.  He is currently a Research Scientist at the Broad Institute.

Isaac Fisher

Ph.D.   Isaac graduated from Slippery Rock University in 2012 and earned his Ph.D. from the University of Rochester in 2020.  He is currently working on understanding the mechanism of PLCb activation by G-proteins in Dr. Angeline Lyon’s laboratory at Purdue University.

Loren Brown PhD

Postdoc Loren conducted his PhD studies in the laboratory of Dr. Paul Insel in the Department of Pharmacology at UC San Diego. He is currently a Research Associate at LSU Health Science Center in New Orleans.

Soneida Rodriguez

Undergraduate Researcher Soneida is a participant in the University of Michigan Research Opportunity Program (UROP).  She is studied the role of Phospholipase C in regulation of cardiac fibrosis.  She is currently working in David Pinsky’s laboratory.

Richard Ransom, Ph.D.

Assistant Research Scientist Richard received his Ph.D. in Biochemistry from Purdue University in 1991, and did postdoctoral work at the University of California, Riverside, and Michigan State University on fungal host-selective, cyclic-peptide toxins.  He has held faculty positions at the University of Michigan and at The Ohio State University prior to joining the Smrcka lab in 2017.  His previous areas of interest include fungal plant pathology, cyclic peptide toxins, kidney glomerular disease, and the mechanism of action of glucocorticoid therapies.  His studied the signaling mechanisms regulated by phospholipase C.

Adrian Campbell, Ph.D.

Research Fellow Adrian received his PhD from University of New South Wales, where he characterized a novel family of allosteric modulators for the α1-adrenergic receptors. In our laboratory he worked on a drug development project, looking for small molecule inhibitors of Gβγ.  He is currently a Senior Scientist at Synature Discovery in Nottingham, UK.

Jerry Madukwe

Graduate Student (URMC) jmadukwe@umich.edu 734-764-9925 5554 MSRB II Jerry received his Ph.D. from the Department of Biochemistry at the University of Rochester.  Jerry will be is a Postdoctoral Researcher at the Yale University School of Medicine where he is doing a structural biology project to elucidate mechanisms of action of receptor tyrosine kinases.

Jesi Lee Anne To

Successfully defended her thesis in the Department of Pharmacology and Physiology at the University of Rochester School of Medicine in April of 2018.  She is currently a Medical Writer at INVIVO Communications in Toronto, Canada.

Rafael Gil de Rubio

Successfully defended his thesis in the Department of Pharmacology and Physiology at the University of Rochester School of Medicine in March of 2018.  He is currently a Scientist at Riparian Pharmaceuticals in Cambridge, MA.