THE LAB 2017-08-23T15:27:38+00:00

Alan Smrcka, Ph.D.

Professor
avsmrcka@umich.edu
734-615-4945
5560C MSRB II

Alan received his Ph.D. in Biochemistry from the University of Arizona and did a Postdoctoral Fellowship with Paul Sternweis at The University of Texas Southwestern Medical Center where he studied G proteins and phospholipase C.

Saji Abraham, Ph.D.

Research Lab Specialist 
Intermediate
Saji@umich.edu
734-764-9925
5554 MSRB II

Saji received his Ph.D is in Botany in 2001 From Mahatma Gandhi University, India.  He is currently working on purifying G proteins for protein crystallization.

Richard Ransom, Ph.D.

Assistant Research Scientist
rransom@umich.edu
734-764-9925
5558 MSRB II

Richard received his Ph.D. in Biochemistry from Purdue University in 1991, and did postdoctoral work at the University of California, Riverside, and Michigan State University on fungal host-selective, cyclic-peptide toxins.  He has held faculty positions at the University of Michigan and at The Ohio State University prior to joining the Smrcka lab in 2017.  His previous areas of interest include fungal plant pathology, cyclic peptide toxins, kidney glomerular disease, and the mechanism of action of glucocorticoid therapies.  His current projects include investigations of signaling mechanisms by phospholipase C and the regulation of phospholipase C epsilon.

Michael Burroughs

Research Lab Specialist Assoc.
mburrou@umich.edu
734-764-9925
5558 MSRB II

Michael has a degree in Biochemistry from SUNY Binghamton.  He is a Lab Research Specialist Associate with experience in screening, protein purification, and rodent colony management.

Craig Nash, Ph.D.

Research Investigator
canash@umich.edu
734-764-9925
5558 MSRB II

Craig completed his PhD at the University of Birmingham, UK in 2011 and after a 3-year post-doc at the University of Leicester, UK, joined the Smrcka lab in February 2015. His current project is focused on the regulation of PLCe by cAMP-mediated pathways, particularly the interplay between positive and negative signals from cAMP.

Adrian Campbell, Ph.D.

Research Fellow
apcamp@umich.edu
734-764-9925
5558 MSRB II

Adrian received his PhD from University of New South Wales, where he characterized a novel family of allosteric modulators for the α1-adrenergic receptors. He is currently undertaking a drug development project, looking for small molecule inhibitors of Gβγ. These compounds can be used for further elucidation of the physiological roles of Gβγ, as well as potential application in the treatment of pain, cardiac hypertrophy and inflammatory conditions.

Loren Brown PhD

Postdoc

Loren conducted his PhD studies in the laboratory of Dr. Paul Insel in the Department of Pharmacology at UC San Diego. He is currently interested in elucidating the mechanisms by which different GPCRs signal through G proteins to induce cardiac hypertrophy.

Rafael Gil de Rubio

Graduate Student (URMC)
rgilder@umich.edu
734-764-9925
5554 MSRB II

In 2011, he received a B.S. in Industrial Biotechnology from the University of Puerto Rico, Mayaguez campus. He joined the lab in 2013 and has been working on subcellular signaling mechanisms by phospholipase C in various cell types.

Naincy Chandan

Graduate Student
nchandan@umich.edu
734-764-9925
5554 MSRB II

Naincy received her bachelors and masters degree in Biotechnology, from India. She joined the Smrcka laboratory in April 2016 and is currently pursuing two diverse projects: A translational project which is based on the development of peptidomimetic inhibitor to prevent cardiac hypertrophy and a cell-biology project to understand Gαi regulation of immune cell migration.

Jesi Lee Anne To

Graduate Student (URMC)
jesileea@umich.edu
734-764-9925
5554 MSRB II

Isaac Fisher

Graduate Student (URMC)
ifisher@umich.edu
734-764-9925
5558 MSRB II

Isaac graduated from Slippery Rock University in 2012.  He is currently working on understanding the mechanism of PLCb activation by G-proteins.

Jerry Madukwe

Graduate Student (URMC)
jmadukwe@umich.edu
734-764-9925
5554 MSRB II

Jerry obtained a B.S. in Biochemistry from Lee University in Cleveland, TN. His work focuses on understanding G protein betagamma subunit regulation of PLCepsilon in the context of cardiac hypertrophy. He is currently trying to identify the domains of PLCepsilon important for its activation by G protein betagamma subunits.